Proteína C reactiva ultrasensible y perfil lipídico posterior a dieta hipocalórica en sujetos obesos

  • Jorly Mejía-Montilla Universidad del Zulia
  • Nadia Reyna-Villasmil Universidad del Zulia
  • Eduardo Reyna-Villasmil Hospital Central Dr. Urquinaona
  • Andreina Fernández-Ramírez Facultad de Humanidades de La Universidad del Zulia. Maracaibo, Venezuela.
  • Pedro Herrera-Moya Universidad Estatal de Milagro
Palabras clave: Proteína C reactiva ultrasensible, Perfil lipídico, Obesidad, dieta de pérdida de peso.


El objetivo del estudio fue comparar los cambios de las concentraciones de proteína C reactiva ultrasensible y perfil lipídico posterior a dieta hipocalórica en sujetos obesos. Fueron incluidos 105 sujetos adultos atendidos en el Hospital Universitario de Maracaibo, Venezuela. Los sujetos fueron instruidos para seguir una dieta hipocalórica durante 12 semanas. Se evaluaron variables antropométricas, concentraciones de proteína C reactiva ultrasensible y perfil lipídico. Se observaron disminuciones significativas en los valores de índice de masa corporal, circunferencia de cintura y proteína C reactiva ultrasensible después del programa de dieta hipocalórica para la pérdida de peso comparado con los valores iniciales (p < 0,05). Se observó disminución significativa de las concentraciones séricas de colesterol total y triglicéridos, después del programa (p = 0,039 y p = 0,028, respectivamente). Las concentraciones séricas de lipoproteínas de baja densidad y alta densidad disminuyeron luego del programa de dieta, pero las diferencias no fueron significativas (p = 0,229 y p = 0,142, respectivamente). Se concluye que las concentraciones de proteína C reactiva ultrasensible, colesterol y triglicéridos disminuyen en forma significativa en sujetos obesos luego de la implementación de un programa de dieta hipocalórica para la pérdida de peso.


La descarga de datos todavía no está disponible.


Ahmadi-Abhari, S., Luben, RN., Wareham, NJ., y Khaw KT. (2013). Seventeen-year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study. European Journal of Epidemiology, 28(7), 541-550.

Ahmadi-Ahangar A. (2016). Predictive ability of C-reactive protein for stroke. Caspian Journal of Internal Medicine, 7(3), 151-152.

Bastard, JP., Jardel, C., Bruckert, E., Blondy, P., Capeau, J., Laville, M., Vidal. H., y Hainque B. (2000). Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. Journal of Clinical Endocrinology and Metabolism, 85(9), 3338-3342.

Caspard. H., Jabbour, S., Hammar, N., Fenici, P., Sheehan, JJ., y Kosiborod, M. (2018). Recent trends in the prevalence of type 2 diabetes and the association with abdominal obesity lead to growing health disparities in the USA: An analysis of the NHANES surveys from 1999 to 2014. Diabetes Obesity and Metabolism, 20(3), 667-671.

Costa, RM., Neves, KB., Tostes, RC., y Lobato NS. (2018). Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity. Frontiers of Physiology, 9, 253.

Florez, H., Castillo-Florez, S., Mendez, A., Casanova-Romero, P., Larreal-Urdaneta, C., Lee, D., y Goldberg, R. (2006). C-reactive protein is elevated in obese patients with the metabolic syndrome. Diabetes Research and Clinical Practice, 71(1), 92-100.

Friedewald, WT., Levy, RI., y Fredrickson, DS. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6), 499-502.

González, AS., Guerrero, DB., Soto, MB., Díaz, SP., Martinez-Olmos, M., y Vidal. O. (2006). Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin. European Journal of Clinical Nutrition, 60(6), 802-809.

Hak, AE., Stehouwer, CD., Bots, ML., Polderman, KH., Schalkwijk, CG., Westendorp, IC., Hofman, A., y Witteman, JC. (1999). Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women. Arteriosclerosis Thrombosis and Vascular Biology, 19(8), 1986-1991.

Hamrefors, V. (2017). Common genetic risk factors for coronary artery disease: new opportunities for prevention? Clinical Physiology and Functional Imaging, 37(3), 243-254.

Ioannidis, JP., y Tzoulaki, I. (2012). Minimal and null predictive effects for the most popular blood biomarkers of cardiovascular disease. Circulation Research, 110(5), 658-662.

Kitagawa, K., Hosomi, N., Nagai, Y., Kagimura, T., Ohtsuki, T., Maruyama, H., Origasa, H., Minematsu, K., Uchiyama, S., Nakamura, M., y Matsumoto, M. (2019). Cumulative Effects of LDL Cholesterol and CRP Levels on Recurrent Stroke and TIA. Journal of Atherosclerosis and Thrombosis, 26(5), 432-441.

Koliaki, C., Liatis, S., y Kokkinos. A. (2019). Obesity and cardiovascular disease: revisiting an old relationship. Metabolism, 92, 98-107.

Krogh-Madsen, R., Plomgaard, P., Keller, P., Keller, C., y Pedersen, BK. (2004). Insulin stimulates interleukin-6 and tumor necrosis factor-alpha gene expression in human subcutaneous adipose tissue. American Journal of Physiology, Endocrinology and Metabolism, 286(2), E234-E238.

Kwagyan, J., Retta, TM., Ketete, M., Bettencourt, CN., Maqbool, AR., Xu, S., y Randall, OS. (2015). Obesity and cardiovascular diseases in a high-risk population: Evidence-based approach to CHD risk reduction. Ethnicity & Disease, 25(2), 208-213.

Lee, JH., Yeom, H., Kim, HC., Suh, I., Kim, MK., Shin, MH., Shin, DH., Koh, SB., Ahn, SV., Lee, TY., Ryu, SY., Song, JS., Choe, HS., Lee, YH., y Choi, BY. (2016). C-reactive protein concentration is associated with a higher risk of mortality in a rural Korean population. Journal of Preventive Medicine and Public Health, 49(5), 275-287.

Lim, U., Monroe, KR., Buchthal, S., Fan, B., Cheng, I., Kristal, BS., Lampe, JW., Hullar, MA., Franke, AA., Stram, DO., Wilkens, LR., Shepherd, J., Ernst, T., y Le Marchand, L. (2019). Propensity for intra-abdominal and hepatic adiposity varies among ethnic groups. Gastroenterology, 156(4), 966-975.e10.

McGill, MR., y Gronowski, AM. (2018). Increased C-Reactive Protein in Healthy Controls. Clinical Chemistry, 64(1), 242-243.

Morita, S., Mizuno, Y., Harada, E., Nakagawa, H., Morikawa, Y., Saito, Y., Katoh, D., Kashiwagi, Y., Yoshimura, M., Murohara, T., y Yasue, H. (2014). Differences and interactions between risk factors for coronary spasm and atherosclerosis--smoking, aging, inflammation, and blood pressure. Internal Medicine, 53(23), 2663-2670.

Nisa, H., Hirata, A., Kohno, M., Kiyohara, C., y Ohnaka, K. (2016). High-sensitivity C-reactive protein and risks of all-cause and cause-specific mortality in a japanese population. Asian Pac Journal of Cancer Prevention, 17(5), 2643-2648.

Onat, A., Avci, GS., Barlan, MM., Uyarel, H., Uzunlar, B., y Sansoy, V. (2004). Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk. International Journal of Obesity and Related Metabolic Disorders, 28(8), 1018-1025.

O'Rourke RW. (2018). Adipose tissue and the physiologic underpinnings of metabolic disease. Surgery for Obesity and Related Disease, 14(11), 1755-1763.

Ouyang, P., Sung, J., Kelemen, MD., Hees, PS., DeRegis, JR., Turner, KL., Bacher, AC., y Stewart, KJ. Relationships of insulin sensitivity with fatness and fitness and in older men and women. Journal of Womens Health (Larchmt), 13(2), 177-185.

Ozen, G., Daci, A., Norel, X., y Topal, G. (2015). Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling. European Journal of Pharmacology. 766, 16-24.

Pickering, RT., Lee, MJ., Karastergiou, K., Gower, A., y Fried, SK. (2016). Depot dependent effects of dexamethasone on gene expression in human omental and abdominal subcutaneous adipose tissues from obese women. PLoS One, 11(12), e0167337.

Ridker, PM., Rifai, N., Rose, L., Buring, JE., y Cook, NR. (2002). Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. New England Journal of Medicine, 347(20), 1557-1565.

Seferović, PM., Ašanin, M., y Ristić AD. (2018). Acute stress disorder and C-reactive protein in patients with acute myocardial infarction. European Journal of Preventive Cardiology, 25(7), 702-705.

Sepehri, ZS., Masoomi, M., Ruzbehi, F., Kiani, Z., Nasiri, AA., Kohan, F., Sheikh Fathollahi, M., Kazemi Arababadi, M., Kennedy, D., y Asadikaram, GA. (2018). Comparison of serum levels of IL-6, IL-8, TGF-β and TNF-α in coronary artery diseases, stable angina and participants with normal coronary artery. Cellular and Molecular Biology (Noisy-le-grand), 64(5), 1-6.

Shivappa, N., Schneider, A., Hébert, JR., Koenig, W., Peters, A., y Thorand, B. (2018). Association between dietary inflammatory index, and cause-specific mortality in the MONICA/KORA Augsburg Cohort Study. European Journal of Public Health, 28(1), 167-172.

Thomas, EL., Parkinson, JR., Frost, GS., Goldstone, AP., Doré, CJ., McCarthy, JP., Collins, AL., Fitzpatrick, JA., Durighel, G., Taylor-Robinson, SD., y Bell, JD. (2012). The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity (Silver Spring), 20(1), 76-87.

Cómo citar
Mejía-Montilla, J., Reyna-Villasmil, N., Reyna-Villasmil, E., Fernández-Ramírez, A., & Herrera-Moya, P. (2020). Proteína C reactiva ultrasensible y perfil lipídico posterior a dieta hipocalórica en sujetos obesos. CIENCIA UNEMI, 13(32), 123-130. Recuperado a partir de
Artículos Científicos

Artículos más leídos del mismo autor/a