Obesity, breast cancer and resistance to antineoplastic treatment: molecular mechanisms
Abstract
Breast cancer is a condition that occurs frequently in women worldwide, and that produces negative and aggressive consequences on health and lifestyle. It is important to know the risk factors and the factors that maintain the disease, in order to prevent its appearance and improve the treatment of the disease. The main objective of the research was to analyze the relationship between obesity and resistance to treatment in breast cancer in order to provide an overview to health professionals about this problem. The research carried out is a narrative review using qualitative methods, since the information obtained is based on the reality of the problems raised in other studies, from which convincing results can be obtained. There is a direct association between obesity and the increase of breast cancer, especially in postmenopausal women, since hormonal regulation is eliminated, which generates weight gain. This in turn causes the gene expression of tumor cells to increase and the cancer does not decrease. In addition, obesity is associated with hormonal alterations, such as an increase in local estrogen production in breast adipose tissue, which may promote growth and resistance to hormonal treatment of breast cancer.Downloads
References
OMS. Obesidad. [Online]; 2022. Disponible en: https://www.who.int/es/health-topics/obesity#tab=tab_1.
Frigolet M, Gutiérrez R. The colors of adipose tissue. GMM. 2020; 156(2).
Devericks E, Carson M, McCullough L, Coleman M, Hursting S. The obesity-breast cancer link: a multidisciplinary perspective. Cancer and Metastasis Reviews. 2022;(41): p. 607-625.
Chooi Y, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019; 92(6).
Avgerinos K, Spyrou N, Mantzoros C, Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism. 2019; 92(12).
Cob E, Cohen S, Cob A. Obesidad y cáncer. Medicina Legal de Costa Rica. 2018; 35(2).
Bevinakoppamath S, Saleh A, Chikkavaddaraguddi S, Vishwanath P, Prashant A. Chemopreventive and Anticancer Property of Selenoproteins in Obese Breast Cancer. Frontiers in Pharmacology. 2021; 12.
Faria S, Correa L, Heyn G, Sant'Ana L, Almeida R, Magalhaes K. Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression, Prognosis, and Therapy. Journal of Breast Cancer. 2020; 23(3).
Martinez T, Sastre J, Ciobu O, Pons D, Roca P. Estrogen Receptor Beta Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer. Antioxidants. 2021; 10(9).
Bhardwaj P, Au C, Martin A, Ladumor H, Oshchepkova S, Moges R, et al. Estrogens and breast cancer: mechanisms involved in obesity-related development, growth and progression. El Diario de Bioquímica de Esteroides y Biología Molecular. 2019; 189.
Maffuz A, Labastida S, Espejo A, Rodríguez S. Características clinicopatológicas del cáncer de mama en una población de mujeres en México. Cirugía y Cirujanos. 2017; 85(3).
Herrera G, Insuasty J, Rodríguez R, Martínez N, Lozano J, Reyes D. Variabilidad del peso en mujeres con cáncer de mama (IIIB), después de tratamiento. Acta Médica Colombia. 2020; 45(3).
Sabol R, Villela V, Freeman B, Hartono A, Wise R. Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling. International Journal of Molecular Sciences. 2020; 21(8).
Palmero J, Lassard J, Juárez L, Medina C. Cáncer de mama: una visión general. Acta médica Grupo Ángeles. 2021; 19(3).
Jo Youn H, Han W. A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors. Epidemiology of Breast Cancer in Asia. 2020; 21(4).
Martinez T, Sastre J, Ciobu N, Oliver J, Pons D, Roca P. Estrogen Receptor Beta (ERβ) Maintains Mitochondrial Estrogen Receptor Beta (ERβ) Maintains Mitochondrial Inflammation Condition in Breast Cancer. Antioxidants. 2021; 10(1371): p. 1-22.
Silveira E, Kliemann N, Sarrafzadegan N. Visceral obesity and incident cancer and cardiovascular disease: An integrative review of the epidemiological evidence. Obes Rev. 2021; 22(1).
Franca A, Romeiro T, De Oliveira M, Pelloso D, Dell C, Rocha S, et al. The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women. The Obesity and the Breast Cancer. 2018; 19.
Corandini D, Oriana S. Impact of sex hormones dysregulation and adiposity on the outcome of postmenopausal breast cancer patients. Clinical Obesity. 2020; 11(1).
De Lima R, Rego G. Influence of Body Mass Index on Survival of Women with Different Subtypes of Breast. Revista Brasileira de Cancerologia. 2019; 65(2).
Kaufer M, Pérez J. La obesidad: aspectos fisiopatológicos y clínicos. Revista Interdisciplina. 2022; 10(26).
Laudisio D, Muscogiuri G, Barrea L, Savastano S, Colao A. Obesity and breast cancer in premenopausal women: Current evidence and future perspectives. Eur J Obstet Gynecol Reprod Biol. 2018; 230(217).
Hamed S, Saadatpour Z, Salmaninejad A, Momeni F, Mokhtari M, Nahand J, et al. Breast cancer diagnosis: Imaging techniques and biochemical markers. Wiley Cellular Physiology. 2017; 233: p. 5200-5213.
García L, Moreno G. Updating the role of obesity and cholesterol in breast cancer. Breast Cancer. 2019; 21(35).
Munsell M, Sprague B, Berry D, Chisholm G. Body mass index and breast cancer risk according to postmenopausal estrogen-progestin use and hormone receptor status. Epidemiol Rev. 2014; 36(1).
Gravena A, Lopes T, Demitto M, Borghesan D, Agnolo C, Brischiliari S. The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women. Asian Pac J Cancer Prev. 2018; 19(9).
Rybinska I, Mangano N, Taglibaue E, Triulzi T. Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences. Int J Mol Sci. 2021; 22(7).
Toledo J, Galeano I. Frecuencia y características clinicopatológicas de mujeres obesas con cáncer de mama del Departamento de Oncología del Hospital de Clínicas. Memorias del Instituto de Investigaciones en Ciencias de la Salud. 2021; 19(1).
Mason C, Wang L, Duggan C, Imayama I, Thomas S, Wang C, et al. Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women. Breast Cancer. 2017; 15.
Cárdenas E, Tenorio A, Ménde J, Orozco L, Leal M, Coral R, et al. Leptin and its receptor are overexpressed in breast cancer tissue of postmenopausal Mexican-Mestizo women with obesity. Annals of Diagnostic Pathology. 2022; 60.
Quiroga L, Sat-Muñoz D, Martínez E, Alcántara R, Macías G. Obesidad y adipocitocinas en cáncer de mama y enfermedad mamaria benigna. Rev Med Inst Mex Seguro Social. 2018;(9).
Coradini D. Impact of sex hormones dysregulation and adiposity on the outcome of postmenopausal breast cancer patients. Clinical Obesity. 2021; 11(1).
Frigolet M, Gutierréz R. The colors of adipose tissue. Gaceta médica de méxico. 2019; 1(1):142-149.
Garcia L, Moreno G. Updating the role of obesity and cholesterol in breast cancer. Breast Cancer Research. 2019; 21(35).
Majlis S. Hormonas femeninas y cáncer de mama: estado de la polémica y evidencias en 2008. ¿que responder a las pacientes? Revista chilena de radiología. 2008; 14(3).
Sánchez C, Valenzuela Y, Pérez A, Villarroel A, Medina L, Camus M, et al. Cáncer de mama avanzado receptor de estrógeno. Rev Chil Cir. 2018; 70(5).
Lee K, Dieli C, Mortimer J. The Impact of Obesity on Breast Cancer Diagnosis and Treatment. Curr Oncol Rep. 2019; 21(5).
Pinheiro R, Monteiro G. Influência do Índice de Massa Corporal na Sobrevida de Mulheres com Diferentes Subtipos de Câncer de Mama: uma Revisão Integrativa. Revista Brasileira de Cancerologia. 2019; 65(2).
Faria S, Correa L, Heyn G, De Santana L, Neves R, Magalhaes K. Obesity and Breast Cancer: The Role of Crown-Like Structures in Breast Adipose Tissue in Tumor Progression,Prognosis, and Therapy. Journal of Breast Cancer. 2020; 23(3).
Herrera G, Insuasty J, Rodríguez R, Martínez N, Lozano J, Reyes D, et al. Variabilidad del peso en mujeres con cáncer Variabilidad del peso en mujeres con cáncer. Revista Acta Médica Colombiana. 2020; 45(3).
Suárez W, Sánchez A, González J. Fisiopatología de la obesidad: Perspectiva actual. Revista chilena de nutrición. 2017; 44(3).
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