Meta-analysis of the efficacy of denosumab versus alendronate in osteoporosis in postmenopausal women
Abstract
Osteoporosis is a worldwide public health problem, increasing morbidity and mortality in postmenopausal women, it is essential to compare the efficacy of anti- osteoporotic agents. A meta-analysis was performed to assess the efficacy of denosumab versus alendronate in the treatment of postmenopausal women with osteoporosis. Randomized controlled clinical trials with percentage increase in total hip bone mineral density (BMD) comparing denosumab and alendronate in postmenopausal women with osteoporosis were included. A total of 3731 were classified as postmenopausal women with osteoporosis, with increases in the percentage of BMD in the total hip (4 clinical trials), 2587 patients received denosumab and 1144 alendronate. The results identified an odds ratio of 1.49 (0.9 to 2.48) with a p value of 0.11 greater than 0.05, indicating that there are no significant differences in the studies of the drugs evaluated. It is concluded that there is no statistically significant difference between the efficacy of denosumab and alendronate in the treatment of osteoporosis in postmenopausal women. However, a larger number of trials are required to corroborate the results obtained.Downloads
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