Vacuna contra la tuberculosis BCG: Eficacia y efectos adversos / BCG vaccine against tuberculosis: Efficacy and adverse effects

  • Steven Quezada Andrade
  • Sunny Sanchez Giler
Palabras clave: análisis, BCG, Ecuador, eficacia, tuberculosis

Resumen

Originada por el Mycobacterium tuberculosis. Esto llevó a la creación de una vacuna que se presentó oficialmente en 1924 y que se conoce como Bacilo Calmette y Guerin (BCG), desde entonces se la ha utilizado. Sin embargo, ha habido numerosas investigaciones sobre su eficacia y otros factores relacionados que han mostrado desequilibrio. Varios países recomiendan el uso de esta vacuna en los recién nacidos, pero en el caso de Ecuador se ha dejado de recomendar su aplicación, a pesar de que no existan datos en relación a la eficacia de la vacuna en dicho país. Otros estudios demuestran que el conocimiento de las personas acerca de la enfermedad es muy pobre, permitiendo así que esta pueda propagarse con mayor facilidad, debido a que la persona infectada no conoce el tipo de sintomatología que la Tuberculosis genera. Este artículo tiene el objetivo de conocer el estado actual de la eficiencia y seguridad de la BCG mediante la revisión y análisis de artículos recopilados relacionados al uso de la vacuna y su eficacia en la población investigada. AbstractTB is the second leading cause of death from an infectious agent, disease caused by Mycobacterium tuberculosis. It allowed the creation of a vaccine officially launched in 1924 and known as Bacillus Calmette-Guerin (BCG) used since then. However, there has been extensive research on its effectiveness and other related factors have shown an imbalance. Several countries recommend the use of this vaccine in infants, but in the case of Ecuador has failed to suggest its application, although there are no data regarding the efficacy of the vaccine in that country. Other studies show that the knowledge of people about the disease is destitute, thus allowing this could spread more quickly because the infected person does not know the type of symptoms that generates Tuberculosis. This article aims to identify the current status of the efficiency and safety of BCG through review and analysis of collected items related to the use of the vaccine and its effectiveness in the research population.

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Citas

(1) Tameris, M., Hatherill, M., Landry, B. S., Scriba,T. J., Snowden, M. A., Lockhart, S., . . . McShane, H. (2013). Safety and effi cacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebocontrolled phase 2b trial. Lancet, 381(9871), 1021-1028.

(2) World Health Organization. (2007). Global tuberculosis control surveillance, planning, financing. WHO report.

(3) World Health Organization. (2010). WHO global tuberculosis control: WHO report 2010. Retrieved from http://apps.who.int/iris/bitstream/10665/44241/1/9789241598866_eng.pdf?ua=1

(4) Uberos, J. (2012). Vacunación frente a la tuberculosis: presente y futuro. Retrieved from Sociedad de Pediatria de Andalucia Oriental: http://ibvacunas.com/wp-content/uploads/tuberculosis.pdf

(5) Cornejo, J., & Perez, J. (2010). Meningitis tuberculosa en niños: una revisión de aspectos clínicos, de laboratorio, epidemiológicos y terapéuticos y de la utilidad de la vacunación con BCG. Iatreja, 23(3), 250-258.

(6) Anderson, E., Webb, E., Mawa, P., Kizza, M., Lyadda, N., Nampijja, M., & Elliot, A. (2012). The influence of BCG vaccine strain on mycobacteriaspecific and non-specific immune responses in a prospective cohort of infants in Uganda. Vaccine, 30(12), 2083-2089. doi:10.1016/j. vaccine.2012.01.053

(7) Rosenthal, S., Loewinsohn, E., Graham, M., Liveright, D., Thorne, M., & Johnson, V. (1961). BCG vaccination against tuberculosis in Chicago. A twenty-year study statistically analyzed. Pediatrics, 28(4), 622-641.

(8) Mahomed, H., Kibel, M., Hawkridge, T., Schaaf, S., Hanekom, W., & Iloni, K. (2006). The impact of a change in bacille Calmette-Guerin vaccine policy on tuberculosis incidence in children in Cape Town, South Africa. Pediatr Infect Dis J, 25(12), 1167-52. doi:10.1097/01. inf.0000243765.33880.54

(9) Sterne, J., Rodrigues, L., & Guedes, I. (1998). Does the efficacy of BCG decline with time since vaccination? Int J Tuberc Lung Dis, 2(3), 200-207.

(10) Rubel, A., & Garro, L. (1992). Social and cultural factors in the successful control of tuberculosis. Public Health Rep, 107(6), 626-36.

(11) Rodrigues, L., Diwan, V., & Wheeler, J. (1993). Protective effect of BCG against tuberculous meningitis and miliary tuberculosis: a metaanalysis. Int J Epidemiol, 22(6), 1154-8.

(12) Buñuel Alvarez, J., & Olivares Gronhert, M. (2006). La vacuna BCG adminsitrada al nacimiento o en los primeros dias de vida es coste efectiva y eficaz para la prevencion de casos de meningitis tuberculosa y tuberculosis miliar en paises de baja renta. Evid Pediatr, 2(56), 97-102.

(13) Teo, S. S., & Shingadia, D. (2006). Does BCG have a role in tuberculosis control and prevention in the United Kingdom? Arch Dis Child, 91(6), 529-31. doi:10.1136/adc.2005.085043

(14) Colditz, G., Berkey, C., Mosteller, F., Brewer, T., Wilson, M., Burdick, E., & Fineberg, H. (1995). The efficacy of bacillus Calmette-Guerin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature. Pediatrics, 96(1), 29-35.

(15) Aronson, J., Aronson, C., & Taylor, H. (1958). A twenty year appraisal of BCG vaccination in the control of tuberculosis. Arch Intern Med, 101(5), 881-893. doi:10.1001/ archinte.1958.00260170037006.

(16) Llanos, F., & Hernan, D. (2012). Asociación entre tuberculosis infantil grave e inmunización previa con BCG en un hospital de referencia nacional, Perú 1990-2000. Peru Med, 29(1), 87-91.

(17) Brewer, T. (2000). Preventing tuberculosis with bacillus Calmette-Guérin vaccine: a meta analysis of the literature. Clin Infect Dis, 31(3),64-7.

(18) Hussey, G., Hawkridge, T., & Hanekom, W. (2007). Childhood tuberculosis: old and new vaccines. Paediatr Respir Rev, 8(2), 148-154.

(19) Marra, C., Marra, F., Cox, V., Palepu, A., & Fitzgerald, M. (2004). Factors influencing quality of life in patients with active tuberculosis. Health Qual Life Outcomes, 2(58), 58-68. doi:10.1186/1477-7525-2-58

(30) Mangtani, P., Abubakar, I., Ariti, C., Beynon, R., Pimpim, L., Fine, P., . . . Sterne, J. (2013). Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials. Clinical Infectious Diseases, 58(4), 470-480. doi:10.1093/cid/cit790.

(21) Palmer, C., & Long, M. (1996). Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis. Am Rev Respir Dis, 94(4), 553-68.

(22) Colditz, G., Brewer, T., Berkey, C., Wilson, M., Burdick, E., Fineberg, H., & Mosteller, F. (1994). Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA, 271(9), 698–702. doi:10.1001/jama.1994.03510330076038.

(23) Iglesias, M., & Montañes, C. (2007). Presente y futuro de la vacuna de la tuberculosis. Retrieved from Vacunas: http://www.vacunas .org/index.php?option=com_content&task=view&id=6352&Itemid=286

(24) Fine, P. (1995). Variation in protection by BCG: implications of and for heterologous immunity. Lancet, 346(8986), 340-347.

(25) Carrizo, J. (2011). Nuevas vacunas de BCG. Archivos Venezolanos de Puericultura y Pediatría, 74(3), 127-134.

(26) Zwerling, A., Behr, M., Verma, A., Brewer, T., Menzies, D., & Pai, M. (2011). The BCG World Atlas: A Database of Global BCG. PLoS Medicine, 8(3), 1-8. doi:10.1371/journal.pmed.1001012

(27) Ministerio de Salud Publica. (2014). Ecuador conmemora el Día Mundial de la Tuberculosis. Retrieved from Ministerio de Salud Publica: http://www.salud.gob.ec/ecuador-conmemorael-dia-mundial-de-la-tuberculosis/

(27) Zwerling, A., Behr, M., Verma, A., Brewer, T., Menzies, D., & Pai, M. (2011). The BCG World Atlas. Retrieved from The BCG World Atlas: http://www.bcgatlas.org/index.php

(29) Pan American Health Organization (PAHO). (2004). Epidemiological status of TB (Region of the Americas). Retrieved from : http://www.paho.org/english/ad/dpc/cd/tb-2004-sit-epi.ppt

(30) Armijos, R., Weigel, M., Qincha, M., & Ulloa, B. (2008). The meaning and consequences of tuberculosis for an at-risk urban group in Ecuador. Panamericana de Salud Publica, 23(3), 188-97.

Publicado
2015-12-14
Cómo citar
Quezada Andrade, S., & Sanchez Giler, S. (2015). Vacuna contra la tuberculosis BCG: Eficacia y efectos adversos / BCG vaccine against tuberculosis: Efficacy and adverse effects. CIENCIA UNEMI, 8(16), 120-125. https://doi.org/10.29076/issn.2528-7737vol8iss16.2015pp120-125p
Sección
Ensayos