Phytochemistry and toxicologic study of native plants of the ecuadorian rain forest

Authors

DOI:

https://doi.org/10.29076/issn.2528-7737vol14iss35.2021pp26-36p

Keywords:

resins, therapeutic effects, embolization

Abstract

There are many native plants in the amazon rain forest whose qualities should be studied to know their toxicity, phytochemical composition and possible medical uses. Our goal was to find in the ecuadorian rain forest plants that have latex and resins to do the preliminary study of their toxicity and phytochemical composition in order to use these plants as embolizing substances to treat some diseases. We looked for the literature to identify some plants located in the Ecuadorian rain forest that have high content of latex and resins. Thirty and three plants were selected, the extracts of five plants were assessed by toxicological and phytochemicals studies using standardize techniques. Williams criteria and Hill logarithm scale for toxicity studies and Chromatogaphic techniques for phytochemical studies. We have found that the extracts of Sapotaceae pouteria aimito, Apocynaceae Lacmellea spaciosa, Moraceae Ficus yoponensis and Euphorbiaceae Sapium glandulosum are toxic according to Williams criteria and they have a high content of resins. Therefore, they should have undertaken to further studies to stablish their posible therapeuthic uses as embolizing agents.

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Author Biographies

  • Vinicio Navas-Flores, Universidad Tecnológica Equinoccial

    Doctor en medicina

  • Ximena Chiriboga-Pazmiño, Universidad Central del Ecuador

    Doctora en Bioquímica y Farmacia

  • Patricio Miño-Cisneros, Universidad Central del Ecuador

    Doctor en Medicina

  • Carmen Luzuriaga- Quichimbo, Universidad Tecnológica Equinoccial

    Doctora en Biología Vegetal

References

Ayala CECM&CM. (1998). Etnobotánica de los Huaoranis de Quehueiri-Ono. Primera ed. Abya-Yala, Quito.

Brassel F, Meila D. (2015). Evolution of Embolic Agents in Interventional Neuroradiology. Clin Neuroradiol. Oct;25 Suppl 2:333-9.

Breevort P. (1998). The Booming U. S. Botanical Market: A New Overview. Herbal Gram 44, 33-46.

Bussmann RW & Douglas S. (2006). Traditional medicinal plant use in Loja province, Southern Ecuador. Journal of Ethnobiology and Ethnomedicine 2, 44.

Bussmann RW, Sharon D. (2015). Plantas medicinales de Los Andes y la Amazonia - La Flora mágica y medicinal del Norte del Perú. Graficart SRL, Trujillo, Perú.

Carneiro A, Teixeira M, Oliveira V, Fernandes O, Cauper G, & Pohlit A. (2008). Screening of Amazonian plants from the Adolpho Ducke forest reserve, Manaus, state of Amazonas, Brazil, for antimicrobial activity. Mem Inst Oswaldo Cruz 1, 31-8.

De la torre L, Navarrete H, Muriel P, Macia, M & Balseo H. (eds). (2008). Encicopedia de las plantas útiles del Ecuador. Herbario QCA de la Escuela de Ciencias Biológicas de la Pontificia Universidad Católica del Ecuador & Herbario AAU del Departamento de Ciencias Biologicas de la Universidad Aarhus. Primera Edición: Enero. Quito & Aarthus.

Díaz W & Ortega F. (2006). Inventario de recursos botánicos útiles y potenciales de la cuenca del río Morón, Estado Carabobo, Venezuela. ERNSTIA 1, 31-67.

Di Cesare D, Du Pont H.L, Mathewson J.J, Ashley D, Martinez-Sandoval F, Pennington J.E, & Porter S.B. (2002). A double blind randomized placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhoea among travellers to Jamaica and Mexico. Am. J. Gastroent. 97, 2585-2588.

Garzón, L. (2016). Conocimiento tradicional sobre las plantas medicinales de yarumo (Cecropia sciadophylla), carambolo (Averrhoa carambola) y uña de gato (Uncaria tomentosa) en el resguardo indígena de Macedonia, Amazonas. Revista Luna Azul [Internet]. 2016 [citado 1 de diciembre 2020] 43: 386-414. Disponible en: http://www.scielo.org.co/pdf/luaz/n43/n43a17.pdf.

Brassel F, Meila D. (2015). Evolution of Embolic Agents in Interventional Neuroradiology. Clin Neuroradiol. Oct;25 Suppl 2:333-9.

Gómez-Cansino R, Espitia-Pinzón C, Campos-Lara M, Guzmán-Gutiérrez S, Segura-Salinas E, Echeverría-Valencia G, Torras-Claveria L, Cuevas-Figueroa X & Reyes-Chilpa R. (2015). Antimycobacterial and HIV-1 Reverse Transcriptase Activity of Julianaceae and Clusiaceae Plant Species from Mexico. Evidence-Based Complementary and Alternative Medicine 1, 1-8.

Holodniy M, Koch J, Mistal M, Schmidt J.M, Khandwala A, Pennington J.E & Porter S.B. (1999). A double blind, randomized placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for symptomatic treatment of diarrhoea in patients with AIS. Am. J. Gastroent 94, 3267-3273.

Hu J, Albadawi H, Chong BW, Deipolyi AR, Sheth RA, Khademhosseini A, Oklu R. (2019). Advances in Biomaterials and Technologies for Vascular Embolization. Adv Mater. Aug;31(33): e1901071.

Hussain, H., Green, R. (2017). A patent review of the therapeutic potential of isoflavones (2012-2016). Expert opinion therapeutic patentes. 27 (10): 1135-1146.

Isaza, J.H. (2007). Taninos o Polifenoles Vegetales. Scientia et Technica. 13 (33): 13-1.

Jørgensen P.M. & León-Yánez S. (1999). Catalogue of the vascular plants of Ecuador. Monogr. Syst. Bot. Missouri Bot. Gard. 75, 1–1182.

León, S., Valencia, R., Pitman, N., Endara, L., Ulloa, C., Navarrete, H. (2011). Libro rojo de las plantas endémicas del Ecuador. 2a edición. Publicaciones del Herbario QCA. Pontificia Universidad Católica del Ecuador, Quito.

Lizcano LJ, Viloria-Bernal M, Vicente F, Berrueta LA, Gallo B, Martínez-Cañamero M, Ruiz-Larrea MB & Ruiz-Sanz JI. (2012). Lipid Oxidation Inhibitory Effects and Phenolic Composition of Aqueous Extracts from Medicinal Plants of Colombian Amazonia. Int. J. Mol. Sci. 13, 5454-5467.

Luzuriaga, C. (2007). Diagnóstico de Flora Estación Biológica Pindo-Mirador. Universidad Tecnológica Equinoccial. Quito-Ecuador.

Martínez-Flórez, S., González-Gallego, J., Culebras, J. y Tuñón, M. (2002). Los flavonoides: propiedades y acciones antioxidantes. Nutrición Hospitalaria. 17 (6): 271-278.

Pollock B, Gorman D & Brown P. (2004). Radiosurgery for arteriovenous malformations of the basal ganglia, thalamus, and brainstem. J. Neurosurgery 2, 210-4.

Ríos, M., Koziol, M., Borgtoft, H. & Granda, G. (2007). Plantas útiles del Ecuador: aplicaciones, retos y perspectivas. Primera edición. Abya-Yala. Quito-Ecuador.

Sobottka, F. Tonial, S. Sytwala, & M. Melzig. (2014). Proteinase activity in latex of three plants of the family Euphorbiaceae. Brazilian Journal of Pharmaceutical Sciences 50, 559-565.

Souza P, Sales P, Simeoni L, Silva E, Silveira D, & Magalhães P. (2012). Inhibitory activity of α-amylase and α-glucosidase by plant extracts from the Brazilian cerrado. Planta Med 78, 393-9.

Tabosa Pereira da Silva C, da Silva Peixoto Sobrinho T, Thijan Nobre de Almeida e Castro V, da Cunha Amaral Lima D & Cavalcanti de Amorim E. (2011). Antioxidant Capacity and Phenolic Content of Caesalpinia pyramidalis Tul. and Sapium glandulosum (L.) Morong from Northeastern Brazil. Molecules 16, 4728-4739. www.mdpi.com/journal/molecules. Acceso 2016-02-20.

Tituaña Pilco M, Yánez Orozco E. (2020). Análisis Florístico y Etnobotánico de la Comunidad Shuin Mamus–Taisha, Amazonía del Ecuador. https://repositorio.uea.edu.ec/handle/123456789/855. Acceso 2020-11-30.

Vandebroek I, Calewaert J, et al. (2004). Use of medicinal plants and pharmaceuticals by indigenous communities in the Bolivian Andes and Amazon. Bulletin of the World Health organization 82, 4.

Vickers W.T. & Plowman T. (1984). Useful Plants of the Siona and Secoya Indians of Eastern Ecuador. Fieldiana Botany New Series No. 15. Field Museum of Natural History. USA. 2019

Wagner H, Bladt S, & Zgainski E. M, (1984). "Plant Drug Analysis. A Thin Layer Chromatography Atlas"; traducido al inglés por T. A. Scott, Springer-Verlag, Berlin-Heildelberg-New York-Tokio.

Wayland C. (2001). Gendering local knowledge: medicinal plant use and primary health care in the Amazon. Medical Anthropology Quarterly 15, 171-88.

Published

2021-01-15

Issue

Section

Artículos Científicos

How to Cite

Phytochemistry and toxicologic study of native plants of the ecuadorian rain forest. (2021). CIENCIA UNEMI, 14(35), 26-36. https://doi.org/10.29076/issn.2528-7737vol14iss35.2021pp26-36p