Evaluation of two local anesthetics plus intraperitoneal dexmedetomidine as adjuvant in multimodal analgesia in veterinary ovariohysterectomy, snap veterinary clinic, Ambato
DOI:
https://doi.org/10.29076/issn.2528-7737vol18iss49.2025pp173-184pKeywords:
OVH , local anesthetics, dexmedetomidine, glosgowAbstract
Introduction: Ovariohysterectomy is one of the most commonly performed surgical procedures in veterinary practice and is frequently associated with considerable pain. This pain is often inadequately managed, underscoring the importance of effective intraoperative and postoperative pain control strategies. Objective: To assess the efficacy of intraperitoneal instillation of two local anesthetics, in combination with dexmedetomidine, as adjuvants within a multimodal pain management protocol in bitches undergoing ovariohysterectomy. Methodology: Five treatment groups were established: T0 (control group), T1 (intraperitoneal lidocaine), T2 (intraperitoneal bupivacaine), T3 (combination of lidocaine and bupivacaine), and T4 (lidocaine plus intraperitoneal dexmedetomidine). Physiological and pharmacological parameters—including heart rate, respiratory rate, oxygen saturation, mean arterial pressure, capnography, body temperature, and Glasgow Composite Pain Scale scores—were assessed at 30 minutes, 8 hours, and 24 hours following surgery. Results: During surgery, pain was observed in 50% of patients in group T0 and 12.5% in T1, whereas 100% of animals in groups T2, T3, and T4 remained pain-free. Statistically significant differences (P < 0.05) were detected in pain scores over time. Groups receiving local anesthetics maintained effective analgesia without requiring rescue analgesia. Conclusion: Intraperitoneal instillation of local anesthetics is an effective strategy for controlling post-surgical pain in ovariohysterectomized bitches, contributing to improved animal welfare and recovery
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References
Axiak, S. (2017). Veterinary anaesthesia and analgesia. Veterinary Anaesthesia and Analgesia, 44(1), P1.
Bennett, R. (2023). A new year and a new era for veterinary anaesthesia and analgesia. Veterinary Anaesthesia and Analgesia, 50(1), 6–8. https://www.vaajournal.org/article/S1467-2987(22)00215-X/abstract
Brioschi, F., Ravasio, G., Ferrari, F., Amari, M., Cesare, D., Visentin, M., & Robbogliatti, V. (2023). Comparison of intraperitoneal and incisional lidocaine or ropivacaine irrigation for postoperative analgesia in dogs undergoing major abdominal surgeries. PLOS ONE, 18(4), e0284379. https://doi.org/10.1371/journal.pone.0284379
Carellán, A., & Casamián, D. (2022). The perioperative management of small animals with previously implanted pacemakers undergoing anaesthesia. Veterinary Anaesthesia and Analgesia. https://doi.org/10.1016/j.vaa.2022.04.003
Chávez, J. (2019). Cicirelli, Vincenzo; Burgio, Matteo; Lacalandra, Giovanni; Aiudi, Giulio [Tesis de posgrado, Universidade Federal de Santa Maria].
Cicirelli, V., Lacalandra, G., Cseh, S., Mrenoshki, D., Lillo, E., Bianchi, F., & Aiudi, G. (2022). Analgesic comparison between topical irrigation (splash block) versus injection of lidocaine on the ovarian pedicle in canine ovariectomy. Veterinary Medicine and Science, 8(5), 1893–1897. https://doi.org/10.1002/vms3.841
Cogo, J., Rodríguez, F., López, M., & Cervino, C. (2021). Estudio comparativo de la anestesia inducida por agonistas α2 combinados con ketaminas en ratas. Revista Argentina de Anestesiología, 79, 11–19. https://ri.conicet.gov.ar/handle/11336/215919
Dehuisser, V., Bosmans, T., Kitshoff, A., Duchateau, L., Rooster, H., & Polis, I. (2019). Effect of premedication on dose requirement, cardiovascular effects and recovery quality of alfaxalone total intravenous anaesthesia in dogs. Veterinary Anaesthesia and Analgesia, 46(4), 421–428. doi: 10.1016/j.vaa.2019.02.008
Fonseca, P. (2022). Comparação entre duas técnicas de cirurgia eletiva em cadelas: ovariohisterectomia por laparotomia e ovariectomia laparoscópica [Tesis de posgrado, Universidade de Évora].
Fossum, T. (2009). Cirugía en pequeños animales (3.ª ed.). Elsevier.
Gates, C., Littlewood, K., Kongara, K., Odom, T., Sawicki, R. (2020). Cross-sectional survey of anaesthesia and analgesia protocols used to perform routine canine and feline ovariohysterectomies. Veterinary Anaesthesia and Analgesia, 47(1), 38–46. doi: 10.1016/j.vaa.2019.06.008
Huayta, J. (2016). Evaluación de cuatro protocolos de anestesia sobre las variaciones en las funciones vitales en la ovariohisterectomía canina. Revista de Investigaciones Veterinarias del Perú, 27(3), 458–466. https://doi.org/10.15381/rivep.v27i3.12289
Jones, R., & West, E. (2019). Environmental sustainability in veterinary anaesthesia. Veterinary Anaesthesia and Analgesia, 46(4), 409–420. https://www.vaajournal.org/article/S1467-2987%2819%2930018-2/fulltext
Julião, G., & Abimussi, C. (2019). Uso de dexmedetomidina em medicina veterinária: revisão de literatura. Revista de Educação Continuada em Medicina Veterinária e Zootecnia, 17(1), 26–32. https://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/37840
Kibar, M., Tuna, B., Kisadere, I., & Güzelbektes, H. (2019). Comparison of instilled lidocaine and procaine effects on pain relief in dogs undergoing elective ovariohysterectomy. Israel Journal of Veterinary Medicine, 74(3), 148–154. https://www.ijvm.org.il/sites/default/files/7kilbar.pdf
Kramer, B., Hellyer, P., Rishniw, M., & Kogan, L. (2021). Anesthetic and analgesic techniques used for dogs undergoing ovariohysterectomies in general practice in the United States. Veterinary Anaesthesia and Analgesia, 49(6), 556–562. doi: 10.1016/j.vaa.2022.07.010.
Lambertini, C., Kluge, K., Lanza, M., Bruhl, R., & Kalchofner, K. (2018). Comparison of intraperitoneal ropivacaine and bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy. Veterinary Anaesthesia and Analgesia, 45(6), 865–870.
Moens, Y., & Drummond, G. (2016). Símbolos en anestesia y analgesia veterinaria: ¿Una torre de Babel? Veterinary Anaesthesia and Analgesia, 588–589.
Monteiro, B., Lascelles, X., Murrell, J., Robertson, S., Steagall, V., & Wright, B. (2022). Directrices de WSAVA para el reconocimiento, evaluación y tratamiento del dolor. WSAVA Global Veterinary Community, 10–19.
Mwangi, W., Mogoa, E., Mwangi, J., Mbuthia, P., & Mbugua, S. (2018). A systematic review of analgesia practices in dogs undergoing ovariohysterectomy. Veterinary World, 11(12), 1725–1732. https://doi.org/10.14202/vetworld.2018.1725-1732
Otero, P. (2012). Protocolos anestésicos y manejo del dolor en pequeños animales: Reporte de casos. Inter-Médica.
Polat, E. (2022). Diagnóstico y tratamiento del caso de cuerpo extraño gástrico (pendiente) en un gato. Revista MVZ Córdoba, 27(3), e2523. https://doi.org/10.21897/rmvz.2523
Reader, R., Olaitan, O., & McCobb, E. (2021). Evaluation of prescribing practices for gabapentin as an analgesic among veterinary professionals. Veterinary Anaesthesia and Analgesia, 48(4), 775–781.
Rocha, P. (2021). Protocolos anestésicos en cesáreas para pacientes caninas ASA I mediante TIVA. [Tesis de pregrado].
Rodrigues, G. (2018). Avaliação de parâmetros fisiológicos com e sem infiltração intraovariana de lidocaína durante o transoperatório de cadelas submetidas à ovariohisterectomia [Tesis de pregrado, Universidade Federal de Uberlândia].
Shah, M., & Gurung, Y. (2023). The effect of local analgesics for postoperative pain control after ovariohysterectomy (OVH) in dogs. The Journal of University Grants Commission, 2(1), 14.
Ullrich, H. (2024). Evaluación del efecto analgésico de la bupivacaína mediante instilación en cirugías de ovariohisterectomía en caninos [Tesis de pregrado, Universidad Estatal de Bolívar].
Ulukan, G., Pekcan, Z., Kadir, Z., Etikan, I., Sayner, S., Zabitler, F., & Eser, F. (2023). Assessing the early postoperative analgesic effects of intraoperative lidocaine–bupivacaine use at the incision line and/or around the ovary in ovariohysterectomy operations of dogs on pain mediators. Pakistan Journal of Zoology, 56(4), 1923–1932.
Viteri, V. (2020). Uso de bupivacaína en infusión continua intraquirúrgica para la disminución de la concentración alveolar mínima de sevoflurano en pacientes sometidos a profilaxis dental en la clínica veterinaria UDLA [Tesis de pregrado, Universidad de Las Américas]
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