Caracterización clínica e histopatológica de la infección por Papiloma Virus humano de muestras de cérvix. Hospital Teodoro Maldonado Carbo “IESS” // Histopathological and clinical characterization of Human Papilloma Virus infection in cervical samples. Teodoro Maldonado Carbo “IESS”
DOI:
https://doi.org/10.29076/issn.2528-7737vol10iss23.2017pp105-111pPalabras clave:
Cáncer, cérvix, dispareunia, gen L1, Papiloma Humano, regiones conservadas // cancer, cervix, dyspareunia, L1 gene, Human Papilloma Virus, conserved regions.Resumen
El Virus del Papiloma Humano (HPV), posee una predilección por los tejidos poliestratificados, con persistencia en capas basales, de allí que a partir de ello es el agente etiológico del cáncer de cérvix, principalmente. Este tipo de cáncer es el segundo más frecuente en mujeres, alrededor del mundo. El HPV es único agente infeccioso oncogénico que lo provoca. Se realizó un trabajo para determinar la prevalencia del virus en mujeres, utilizando técnicas de detección de ADN mediante PCR, en tiempo real, a partir de biopsia de cérvix, además de establecer las características histopatológicas y clínicas relacionadas. La prevalencia fue del 30,67%, la presentación histopatológica más frecuentemente infectada fue el Cáncer de cérvix y el in situ. Mientras más displásica es la histopatología del cérvix, más frecuente es la presentación del virus. Se demostró una asociación entre la exposición a la infección y la presencia de secreción vaginal blanquecina y la dispareunia.
ABSTRACT
Human Papilloma Virus (HPV) has a predilection for poly-stratified tissues, with persistence in the basal layers, hence mainly is the etiological agent of cervical cancer. Cervical cancer is the second most common cancer in women worldwide. HPV is unique oncogenic infectious agent that causes it. The objective of the study was to determine the prevalence of the virus in women, using DNA detection techniques through PCR, in real-time, from the cervical biopsy. In addition, the related histopathological and clinical characteristics were established. The prevalence was 30.67%, the most frequently infected histopathology presentation was cervical and in situ cancer. The more dysplastic the histopathology of the cervix, the more frequent the presentation of the virus. An association between exposure to infection and the presence of whitish vaginal discharge and dyspareunia was demonstrated.
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Almonte, M., Albero, G., Molano, M., Carcamo, C., Garcia, P. J., & Perez, G. (2008). Risk factors for human papillomavirus exposure and co-factors for cervical cancer in Latin America and the Caribbean. Vaccine, 26. https://doi.org/10.1016/j.vaccine.2008.06.008
Bava, S. V., Thulasidasan, A. K. T., Sreekanth, C. N., & Anto, R. J. (2016). Cervical cancer: A comprehensive approach towards extermination. Annals of Medicine, 48(3), 149-161. https://doi.org/10.3109/07853890.2016.1145796
Bjurberg, M., Beskow, C., Kannisto, P., & Lindahl, G. (2015). [Cervical cancer is a clinical challenge]. Lakartidningen, 112.
Boden, E., Eriksson, A., Rylander, E., & von Schoultz, B. (1988). Clinical characteristics of papillomavirus-vulvovaginitis. A new entity with oncogenic potential. Acta Obstetricia et Gynecologica Scandinavica, 67(2), 147-151.
Boden, E., Rylander, E., Evander, M., Wadell, G., & von Schoultz, B. (1989). Papilloma virus infection of the vulva. Acta Obstetricia et Gynecologica Scandinavica, 68(2), 179-184.
Bruni L, Barrionuevo-Rosas L, Serrano B, Brotons M, Cosano R, Muñoz J, … Castellsagué X. (2013). Human Papillomavirus and Related Diseases in Ecuador. Summary Report . ICO Information Centre on HPV and Cancer (HPV Information Centre).
Camargo, M., Soto-De Leon, S. C., Munoz, M., Sanchez, R., Peña-Herrera, D., Pineda-Peña, A. C., … Patarroyo, M. A. (2014). Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia. BMC Cancer, 14(1), 1-10. https://doi.org/10.1186/1471-2407-14-451
Correnti, M., Medina, F., Cavazza, M. E., Rennola, A., Ávila, M., & Fernándes, A. (2011). Human papillomavirus (HPV) type distribution in cervical carcinoma, low-grade, and high-grade squamous intraepithelial lesions in Venezuelan women. Gynecologic Oncology, 121(3), 527-531. https://doi.org/10.1016/j.ygyno.2011.02.003
De Sanjosé, S., Serrano, B., Castellsagué, X., Brotons, M., Muñoz, J., Bruni, L., & Bosch, F. X. (2012). Human papillomavirus (HPV) and related cancers in the Global Alliance for Vaccines and Immunization (GAVI) countries. A WHO/ICO HPV Information Centre Report. Vaccine, 30(Suppl 4), D1–83.
Goldie, S. J., Gaffikin, L., Goldhaber-Fiebert, J. D., Gordillo-Tobar, A., Levin, C., Mahe, C., & Wright, T. C. (2005). Cost-effectiveness of cervical-cancer screening in five developing countries. The New England Journal of Medicine, 353(20), 2158-2168. https://doi.org/10.1056/NEJMsa044278
Goodman, A. (2015). HPV testing as a screen for cervical cancer. BMJ (Clinical Research Ed.), 350, h2372.
Grinsztejn, B., Veloso, V. G., Levi, J. E., Velasque, L., Luz, P. M., Friedman, R. K., … Palefsky, J. (2009). Factors associated with increased prevalence of human papillomavirus infection in a cohort of HIV-infected Brazilian women. Int J Infect Dis, 13. https://doi.org/10.1016/j.ijid.2008.03.031
Horton, S., & Gauvreau, C. L. (2015). Cancer in Low- and Middle-Income Countries: An Economic Overview. En H. Gelband, P. Jha, R. Sankaranarayanan, & S. Horton (Eds.), Cancer: Disease Control Priorities, Third Edition (Volume 3). Washington (DC): The International Bank for Reconstruction and Development / The World Bank.
Hutter, J. N., & Decker, C. F. (2016). Human papillomavirus infection. Disease-a-Month : DM, 62(8), 294-300. https://doi.org/10.1016/j.disamonth.2016.03.014
Iwasaki, R., Galvez-Philpott, F., Arias-Stella Jr., J., & Arias-Stella, J. (2014). Prevalence of high-risk human papillomavirus by cobas 4800 HPV test in urban Peru. Brazilian Journal of Infectious Diseases, 18, 469-472.
Lee, S. H., Vigliotti, J. S., Vigliotti, V. S., & Jones, W. (2014). From Human Papillomavirus (HPV) Detection to Cervical Cancer Prevention in Clinical Practice. Cancers, 6(4), 2072-2099. https://doi.org/10.3390/cancers6042072
Murillo, R., Molano, M., Martínez, G., Mejía, J.-C., & Gamboa, O. (2009). HPV Prevalence in Colombian Women with Cervical Cancer: Implications for Vaccination in a Developing Country. Infectious Diseases in Obstetrics and Gynecology, 2009, 9. Recuperado a partir de http://dx.doi.org/10.1155/2009/653598
Richart, R. M. (1969). A theory of cervical carcinogenesis. Obstetrical & Gynecological Survey, 24(7 Pt 2), 874-879.
Richart, R. M. (1973). Cervical intraepithelial neoplasia. Pathology Annual, 8, 301-328.
Sánchez-Lander, J., Cortiñas, P., Loureiro, C. L., Pujol, F. H., Medina, F., Capote-Negrín, L., … Acosta, H. (2012). Human papillomavirus in invasive cervical cancer and cervical intraepithelial neoplasia 2 and 3 in Venezuela: A cross-sectional study. Cancer Epidemiology, 36(5), e284-e287. https://doi.org/10.1016/j.canep.2012.04.005
Soost, H. J., Lange, H. J., Lehmacher, W., & Ruffing-Kullmann, B. (1991). The validation of cervical cytology. Sensitivity, specificity and predictive values. Acta Cytologica, 35(1), 8-14.
Spencer Eugenio, A. L. F., & Ferrés Marcela. (2011). Virología clínica. Santiago de Chile: Mediterráneo Ltda.
Strand, A., & Rylander, E. (1998). Human papillomavirus. Subclinical and atypical manifestations. Dermatologic Clinics, 16(4), 817-822.
Wikstrom, A. (1995). Clinical and serological manifestations of genital human papillomavirus infection. Acta Dermato-Venereologica. Supplementum, 193, 1-85.
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