Symptoms and possible risks of COVID-19 in pregnant women
DOI:
https://doi.org/10.29076/issn.2602-8360vol7iss12.2023pp59-66pKeywords:
pregnancy, coronavirus infections, SARS virus, severe acute respiratory syndromeAbstract
The disease caused by the novel coronavirus SARS-CoV-2 (COVID-19) has become a worldwide public health problem. Several viral infections such as SARS, MERS, and influenza have been associated with adverse outcomes during pregnancy. The objective of this study was to determine the symptoms and possible risks in pregnant women infected with SARS-CoV-2, as well as the complications in fetuses and newborns whose mothers were infected by the novel coronavirus. A literature review in English and Spanish was performed in order to retrieve information about the risks of COVID-19 during pregnancy. Data were retrieved from scientific publications available on the Web of Science, Cochrane, PubMed, and Scopus websites. The observed results were in pregnant patients, the first symptoms of COVID-19 were fever, cough, dyspnea, myalgia, and fatigue; while headache, hemoptysis, diarrhea, and sputum were less common. The majority of studies found no evidence of vertical maternal-fetal transmission in pregnant women with COVID-19. It is concluded that pregnant women do not appear to be more susceptible to the consequences of COVID-19 infection, in contrast to the general population. However, within the evolution of the disease, it must be taken into account that there are risk factors such as prematurity or fetal distress; although the possibility of transplacental transmission has not been fully proven.
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Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR Am J Roentgenol. 2020; 215(1):127–32.
Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020; 222(6):521–31.
Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. American Journal of Obstetrics and Gynecology. 2020; 222:415–426.
Zhang L, Jiang Y, Wei M, Cheng BH, Zhou XC, Li J, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi. 2020; 25;55(3):166-171. doi: 10.3760/cma.j.cn112141-20200218-00111.
Masmejan S, Pomar L, Lepigeon K, Favre G, Baud D, Rieder W. COVID-19 and pregnancy. Rev Med Suisse. 2020; 16(692):944–6.
Rajewska A, Mikołajek-Bedner W, Lebdowicz-Knul J, Sokołowska M, Kwiatkowski S, Torbé A. COVID-19 and pregnancy-where are we now? A review. Journal of Perinatal Medicine. 2020; 48: 428–434.
Alzamora MC, Paredes T, Caceres D, Webb CM, Webb CM, Valdez LM, et al. Severe COVID-19 during Pregnancy and Possible Vertical Transmission. Am J Perinatol. 2020; 37(8):861–865.
Schwartz DA. An analysis of 38 pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: Maternal coronavirus infections and pregnancy outcomes. Arch Pathol Lab Med. 2020; 144(7):799–805.
Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical record. Lancet. 2020; 395(10226):809–15.
Wang S shuai, Zhou X, Lin X guang, Liu Y yan, Wu J li, Sharifu LM, et al. Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital, China. Curr Med Sci. 2020; 40(2):285–9.
Phoswa WN, Khaliq OP. Is pregnancy a risk factor of COVID-19? European Journal of Obstetrics and Gynecology and Reproductive Biology. 2020; 252:605-609. doi: 10.1016/j.ejogrb.2020.06.058.
Jamieson DJ, Steinberg JP, Martinello RA, Perl TM, Rasmussen SA. Obstetricians on the Coronavirus Disease 2019 (COVID-19) Front Lines and the Confusing World of Personal Protective Equipment. Obstet Gynecol. 2020; 135(6):1257–1263.
Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics. Otolaryngol - Head Neck Surg. 2020; 163(1):114–120.
Bulut C, Kato Y. Epidemiology of covid-19. Turkish Journal of Medical Sciences. 2020; 50: 563–570.
De Wit E, Van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: Recent insights into emerging coronaviruses. Nature Reviews Microbiology. 2016; 14: 523–534.
Lee KS. Pneumonia associated with 2019 novel coronavirus: Can computed tomographic findings help predict the prognosis of the disease? Korean Journal of Radiology. 2020; 21(3):257-258. doi: 10.3348/kjr.2020.0096.
Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The incubation period of coronavirus disease 2019 (CoVID-19) from publicly reported confirmed cases: Estimation and application. Ann Intern Med. 2020; 172(9):577–582.
Parisa Maleki D, Fariba K, Fatemeh S, Bahram M, Shahla C, Zatollah A. COVID-19 and pregnancy: a review of current knowledge. Le Infez Med. 2020; 28(1):46–51.
Yu ITS, Li Y, Wong TW, Tam W, Chan AT, Lee JHW, et al. Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus. N Engl J Med. 2004; 350(17):1731–1739.
Lopez Zuñiga D, López Zuñiga MA. COVID-19 diagnosis through image. Med Clin (Barc). 2020;155(3):140.
Velavan TP, Meyer CG. The COVID-19 epidemic. Tropical Medicine and International Health. 2020; 25(3):278-280. doi: 10.1111/tmi.13383.
Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4):420–422.
Jing Y, Run-Qian L, Hao-Ran W, Hao-Ran C, Ya-Bin L, Yang G, et al. Potential influence of COVID-19/ACE2 on the female reproductive system. Molecular human reproduction. 2020; 26:367–373.
Lan L, Xu D, Ye G, Xia C, Wang S, Li Y, et al. Positive RT-PCR Test Results in Patients Recovered from COVID-19. JAMA Journal of the American Medical Association. 2020; 323(15): 1502–1503. doi:10.1001/jama.2020.2783.
Ministerio de Sanidad República de España. Documento Técnico. Manejo de la mujer embarazada y el recién nacido con COVID 19. 2020. p. 19–21. Disponible en: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Documento_manejo_embarazo_recien_nacido.pdf
Borre-Naranjo D, Santacruz J, Gonzalez-Hernandez J, Anichiarico W, Rubio-Romero J. Infección por SARS-CoV-2 en la paciente obstétrica: una perspectiva desde el cuidado crítico. Acta Colomb Cuid Intensivo. 2020; 20(2):98–107.
Nana M, Nelson-Piercy C. COVID-19 in pregnancy. Clin Med (Lond). 2021; 21(5):e446-e450. doi: 10.7861/clinmed.2021-0503
Herrera M, Arenas J, Rebolledo M, Baron J, De Leon J, Yomayusa N, et al. Embarazo e Infección por Coronavirus COVID 19 Información para Profesionales de la salud. Por Fundación Internacional de Medicina Materno Fetal Guías y Flujograma de Manejo: COVID 19 y Embarazo de la FIMMF. 2020.
Córdoba Vive S, Fonseca Peñaranda G. COVID-19 y Embarazo. Rev Med Costa Rica. 2020; 85(629):22–26.
Organización Panamericana de la Salud, Organización Mundial de la Salud. Cuidar a mujeres embarazadas y recién nacidos con confirmación o sospecha de COVID-19. 2020 Mar.
Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res. 2020; 178:104787.
Nicolas P, Maia MF, Bassat Q, Kobylinski KC, Monteiro W, Rabinovich NR, et al. Safety of oral ivermectin during pregnancy: a systematic review and meta-analysis. Lancet Glob Heal. 2020; 8(1): 92–100.
Sharma KA, Kumari R, Kachhawa G, Chhabra A, Agarwal R, Sharma A, et al. Management of the first patient with confirmed COVID-19 in pregnancy in India: From guidelines to frontlines. Int J Gynecol Obstet. 2020; 150(1):116–118.
Ministerio de Salud de Colombia. Lineamiento para el uso de pruebas de laboratorio de Salud Pública (LSP) en el marco de la emergencia sanitaria por COVID 19 en Colombia. Ministerio Salud de Colombia. 2020. p. 1–19. Available from: https://www.minsalud.gov.co/RID/lineamientos-pruebas-lsp-covid-19.pdf
Stephens AJ, Barton JR, Bentum NAA, Blackwell SC, Sibai BM. General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic. American Journal of Perinatology. 2020; 37:829–836.
Juan J, Gil MM, Rong Z, Zhang Y, Yang H, Poon LC. Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound in Obstetrics and Gynecology. 2020; 56:15–27.
Caparros González R. Maternal and neonatal consequences of coronavirus COVID-19 infection during pregnancy: a scoping review. Rev Esp Salud Pública. 2020; 94: e202004033.
Herrera J., Montero J., Campos S., Covid-19 y embarazo: revisión de la bibliografía actual. Revista Médica Sinergia. 2020; 5(9):4-12.
Serna C., Moreno V., González M., Cruz J., enfermedad infecciosa por coronavirus COVID-19 en la mujer embarazada y neonato: impacto clínico y recomendaciones. Metas Enferm. 2020; 23(5):22-32
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