Behavior of the infant mortality rate, after a timely immunization: Systematic Review

Authors

DOI:

https://doi.org/10.29076/issn.2602-8360vol7iss13.2023pp66-73p

Keywords:

mortality rate, immunization, children

Abstract

The effects on mortality presented by vaccines, especially BCG, which presents the strongest evidence, due to randomized studies carried out in Guinea-Bissau; It seems to encompass not only direct protection, but apparently generates a good heterogeneous adaptive immune response. A systematic review was carried out, with the objective to analyze the behavior of the infant mortality rate after timely immunization, through the consultation of scientific articles in different reliable databases with the application of DeCS and MeSH. The collection of articles was systematic, for which the PRISMA declaration was used. The authors mostly agreed that timely immunization produces a decrease in the infant mortality rate, especially in low-resource countries where the risk of contracting any of these pathologies is greater. However, one of the studies carried out in the United States showed an increase in the infant fatality rate when a greater number of doses is applied. Concluding that vaccines turned out to be effective in reducing the infant mortality rate, particularly in low-income territories.

Downloads

Download data is not yet available.

References

Goodridge H, Ahmed S, Curtis N, Kollmann T, Levy O, Netea M, et al. Harnessing the beneficial heterologous effects of vaccination. Nat Rev Immunol. 2016;16(6):9.

Whittaker E, Goldblatt D, McIntyre P, Levy O. Neonatal Immunization: Rationale, Current State, and Future Prospects. Front Immunol. 2018;9(1):5.

Kallon S, Samir S, Goonetilleke N. Vaccines: Underlying Principles of Design and Testing. Clin Pharmacol Ther. 2021;109(4):92.

Higgins J, Soares K, López J, Kakourou A, Chaplin K, Christensen H, et al. Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review. BMJ. 2016;355:5170.

Moorlag S, Arts R, van Crevel R, Netea M. Non-specific effects of BCG vaccine on viral infections. Clin Microbiol Infect. 2019;25(12):8.

Dockrell H, Butkeviciute E. Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine? Vaccine. 2022;40(11):9.

Mina M, Metcalf C, De Swart R, Osterhaus A, Grenfell B. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science. 2015;348(6235):694.

Sørup S, Stensballe L, Krause T, Aaby P, Benn C, Ravn H. Oral Polio Vaccination and Hospital Admissions With Non-Polio Infections in Denmark: Nationwide Retrospective Cohort Study. Open Forum Infect Dis. 2016;3(1).

Flanagan K, Van Crevel R, Curtis N, Shann F, Levy O. Heterologous (“Nonspecific”) and Sex-Differential Effects of Vaccines: Epidemiology, Clinical Trials, and Emerging Immunologic Mechanisms. Clin Infect Dis An Off Publ Infect Dis Soc Am. 2013;57(2):7.

Bayard V, DeAntonio R, Contreras R, Tinajero O, Castrejon MM, Ortega-Barría E, et al. Impact of rotavirus vaccination on childhood gastroenteritis-related mortality and hospital discharges in Panama. Int J Infect Dis. 2012;16(2):94–8.

Biering-Sørensen S, Aaby P, Napirna BM, Roth A, Ravn H, Rodrigues A, et al. Small randomized trial among low-birth-weight children receiving bacillus Calmette-Guéerin vaccination at first health center contact. Pediatr Infect Dis J. 2012;31(3):306–8.

Goldman GS, Miller NZ. Relative trends in hospitalizations and mortality among infants by the number of vaccine doses and age, based on the Vaccine Adverse Event Reporting System (VAERS), 1990-2010. Hum Exp Toxicol. 2012;31(10):1012–21.

Fisker AB, Hornshøj L, Rodrigues A, Balde I, Fernandes M, Benn CS, et al. Effects of the introduction of new vaccines in Guinea-Bissau on vaccine coverage, vaccine timeliness, and child survival: An observational study. Lancet Glob Heal. 2014;2(8):e478–87.

Rasooly MH, Govindasamy P, Aqil A, Rutstein S, Arnold F, Noormal B, et al. Success in reducing maternal and child mortality in Afghanistan. Glob Public Health. 2014;9(SUPPL.1):37–41.

Aaby P, Martins CL, Garly ML, Andersen A, Fisker AB, Claesson MH, et al. Measles vaccination in the presence or absence of maternal measles antibody: Impact on child survival. Clin Infect Dis. 2014;59(4):484–92.

Schurink-van’t Klooster TM, Knol MJ, de Melker HE, van der Sande MAB. Gender-specific mortality in DTP-IPV- and MMR ± MenC-eligible age groups to determine possible sex-differential effects of vaccination: An observational study. BMC Infect Dis. 2015;15(1):1–9.

Rurangwa J, Rujeni N. Decline in child hospitalization and mortality after the introduction of the 7-valent pneumococcal conjugative vaccine in Rwanda. Am J Trop Med Hyg. 2016;95(3):680–2.

Byberg S, Østergaard MD, Rodrigues A, Martins C, Benn CS, Aaby P, et al. Analysis of risk factors for infant mortality in the 1992-3 and 2002-3 birth cohorts in rural Guinea-Bissau. PLoS One. 2017;12(5):1–15.

McCarthy N, Sukumaran L, Newcomer S. Patterns of childhood immunization and all-cause mortality Natalie. Physiol Behav. 2017;176(5):498–503.

Sánchez-Ramos EL, Monárrez-Espino J, Noyola DE. Impact of vaccination on influenza mortality in children <5 years old in Mexico. Vaccine. 2017;35(9):1287–92.

Biering-Sørensen S, Aaby P, Lund N, Monteiro I, Jensen KJ, Eriksen HB, et al. Early BCG-Denmark and Neonatal Mortality among Infants Weighing <2500 g: A Randomized Controlled Trial. Clin Infect Dis. 2017;65(7):1183–90.

Schaltz-Buchholzer F, Biering-Sørensen S, Lund N. Early Bacille Calmette-Guérin vaccination, hospitalizations and hospital deaths: Analysis of a secondary outcome in three randomized trials from Guinea-Bissau Schaltz-Buchholzer. Journals Gerontol Ser A Biol Sci Med Sci. 2018;813(4):1–11.

Welaga P, Debpuur C, Aaby P, Hodgson A, Azongo DK, Benn CS, et al. Is the decline in neonatal mortality in northern Ghana, 1996-2012, associated with the decline in the age of BCG vaccination? An ecological study. BMJ Open. 2018;8(12):1–9.

Andersen A, Fisker AB, Rodrigues A, Martins C, Ravn H, Lund N, et al. National Immunization Campaigns with Oral Polio Vaccine Reduce All-Cause Mortality: A Natural Experiment within Seven Randomized Trials. Front Public Heal. 2018;6(February):1–10.

Briko NI, Korshunov VA, Baranov AA, Kostenko NA, Vishneva EA, Grinchik PR. Evaluación de la efectividad de la vacunación de lactantes con una vacuna antineumocócica conjugada 13-valente en el marco del Calendario Nacional de Vacunación de Rusia. Probl la pediatría Mod. 2019;18(3):2016–7.

Jaupart P, Dipple L, Dercon S. Has Gavi lived up to its promise? Quasi-experimental evidence on country immunisation rates and child mortality. BMJ Glob Heal. 2019;4(6):1–11.

Nayir T, Nazlican E, Şahin M, Kara F, Alp Meşe E. Effects of immunization program on morbidity and mortality rates of vaccine-preventable diseases in Turkey. Turkish J Med Sci. 2020;50(8):1909–15.

Nielsen S, Khalek MA, Benn CS, Aaby P, Hanifi SMA. National immunisation campaigns with oral polio vaccine may reduce all-cause mortality: Analysis of 2004–2019 demographic surveillance data in rural Bangladesh. EClinicalMedicine. 2021;36:100886.

Quinn MK, Edmond KM, Fawzi WW, Hurt L, Kirkwood BR, Masanja H, et al. Non-specific effects of BCG and DTP vaccination on infant mortality: An analysis of birth cohorts in Ghana and Tanzania. Vaccine. 2022;40(27):3737–45.

Critical Appraisal Skills Programme (CASP) Randomised Controlled Trial. CASP Randomised Controlled Trial Standard Checklist - casp-uk.net. CASP checklists Oxford [Internet]. 2013;(2020):1–7.

Yepes-Nuñez JJ, Urrútia G, Romero-García M, Alonso-Fernández S. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Rev Esp Cardiol. 2021;74(9):790–9.

Published

2023-12-17

How to Cite

Behavior of the infant mortality rate, after a timely immunization: Systematic Review. (2023). FACSALUD-UNEMI, 7(13), 66-73. https://doi.org/10.29076/issn.2602-8360vol7iss13.2023pp66-73p