Appreciation of the role of luteinizing hormone and its attributes as a diagnostic method for identifying early puberty
DOI:
https://doi.org/10.29076/issn.2602-8360vol8iss15.2024pp46-53pKeywords:
hormone, luteinizing, puberty, precociousAbstract
Precocious puberty is a hormonal alteration in infants, which leads to the development of mature sexual characteristics ahead of time; In recent years, the number of cases in consultation has increased, which is why the objective was to carry out an updated systematic review on the properties of luteinizing hormone, focusing on its detection capacity and cut-off value to identify precocious puberty in the population. pediatric population. The article was based on a systematic literature review, by searching for scientific articles published from 2019 to 2024 in the PubMed, Cochrane, ScienceDirect and MEDLINE databases. Nine researches were studied that differ in terms of the relevant properties of the luteinizing hormone test. It has not been possible to reach a consensus on the appropriate time to perform and evaluate this test, as it can vary between 30 and 60 minutes, even up to 180 minutes. Furthermore, the changes are notable with respect to the cut-off point; specificity and sensitivity, which is why it is important to carry out new lines of research that encourage establishing certain values that guide health personnel to reach the diagnosis of precocious puberty.
Downloads
References
1. Tang J, Xue P, Huang X, Lin C, Liu S. Diet and Nutrients Intakes during Infancy and Childhood in Relation to Early Puberty: A Systematic Review and Meta-Analysis. Nutrients. 2022;14(23). doi: 10.3390/nu14235004
2. Prosperi S, Chiarelli F. Early and precocious puberty during the COVID-19 pandemic. Front Endocrinol. 2022;13. doi: 10.3389/fendo.2022.1107911
3. Shi L, Jiang Z, Zhang L. Childhood obesity and central precocious puberty. Front Endocrinol. 2022;13:1056871. doi: 10.3389/fendo.2022.1056871
4. Liu G, Guo J, Zhang X, Lu Y, Miao J, Xue H. Obesity is a risk factor for central precocious puberty: a case-control study. BMC Pediatr. 2021;21(1). Disponible en: doi: 10.1186/s12887-021-02936-1
5. Chen YS, Liu CF, Sung MI, Lin SJ, Tsai WH. Machine Learning Approach for Prediction of the Test Results of Gonadotropin-Releasing Hormone Stimulation: Model Building and Implementation. Diagnostics. 2023;13(9):1550. doi: 10.3390/diagnostics13091550
6. Yeh SN, Ting WH, Huang CY, Huang SK, Lee YC, Chua WK, et al. Diagnostic evaluation of central precocious puberty in girls. Pediatr Neonatol. 2021;62(2): 187-194
7. Lee DM, Chung IH. Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty. Ann Pediatr Endocrinol Metab. 2019;24(1):27-33. doi: 10.6065/apem.2019.24.1.27
8. Tripathy M, Baliarsinha A, Choudhury A, Das UK. The Role of Urinary LH and FSH in the Diagnosis of Pubertal Disorders. Indian J Endocrinol Metab. 2021;25(2): 110-120. doi: 10.4103/ijem.IJEM_47_21
9. Heo S, Lee Y, Yu J. Basal serum luteinizing hormone value as the screening biomarker in female central precocious puberty. Ann Pediatr Endocrinol Metab. 2019;24(3):164-171. doi: 10.6065/apem.2019.24.3.164
10. Ouyang L, Yang F. Combined diagnostic value of insulin-like growth factor-1, insulin-like growth factor binding protein-3, and baseline luteinizing hormone levels for central precocious puberty in girls. J Pediatr Endocrinol Metab JPEM. 2022;35(7):874-879. doi: 10.1515/jpem-2022-0161
11. Sodero G, Pane LC, Di Sarno L, Rigante D, Cipolla C. GnRH test for the diagnosis of central precocious puberty: is it time to revisit the protocol? Clin Pediatr Endocrinol. 2023;32(3):192-194. doi: 10.1297/cpe.2023-0011
12. Cao R, Liu J, Fu P, Zhou Y, Li Z, Liu P. The Diagnostic Utility of the Basal Luteinizing Hormone Level and Single 60-Minute Post GnRH Agonist Stimulation Test for Idiopathic Central Precocious Puberty in Girls. Front Endocrinol. 2021;12: 713880. doi: 10.3389/fendo.2021.713880
13. Cipolla C, Sodero G, Pane LC, Mariani F, Di Sarno L, Rigante D, et al. Auxological and Metabolic Parameters of Children Undergoing the Gonadotropin-Releasing Hormone Stimulation Test: Correlations with the Final Diagnosis of Central Precocious Puberty in a Single-Center Study. Biomedicines. 2023;11(6):1678. doi: 10.3390/biomedicines11061678
14. Vukovic R, Milenkovic T, Soldatovic I, Pekic S, Mitrovic K, Todorovic S. Triptorelin stimulated luteinizing hormone concentrations for diagnosing central precocious puberty: study of diagnostic accuracy. Endocrine. 2022;75(3):934-41. doi: 10.1007/s12020-021-02947-z
15. Gangat M, Radovick S. Precocious puberty. Minerva Pediatr. 2020;72(6):491-500. doi: 10.23736/S0026-4946.20.05970-8
16. Lee SY, Kim JM, Kim YM, Lim HH. Single random measurement of urinary gonadotropin concentration for screening and monitoring girls with central precocious puberty. Ann Pediatr Endocrinol Metab. 2021;26(3):178-184. doi: 10.6065/apem.2040208.104
17. Baronio F, Assirelli V, Deiana G, AlQaisi R, Ortolano R, Di Natale V, et al. Does Basal Morning Luteinizing Hormone (bLH) Predict Central Precocious Puberty (CPP) in Girls? Medicina (Mex). 2024;60(3):497. doi: 10.3390/medicina60030497
18. Ab Rahim SN, Omar J, Tuan Ismail TS. Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review. Ann Pediatr Endocrinol Metab. 2020;25(3):152-155. doi: 10.6065/apem.2040004.002
19. Özalkak Ş, Çetinkaya S, Budak FC, Erdeve ŞS, Aycan Z. Evaluation of Gonadotropin Responses and Response Times According to Two Different Cut-Off Values in Luteinizing Hormone Releasing Hormone Stimulation Test in Girls. Indian J Endocrinol Metab. 2020;24(5):410-415. doi: 10.4103/ijem.IJEM_314_20
20. Phadte A, Sarathi V, Budyal S, Lila A, Memon SS, Karlekar M, et al. Gonadotropin-Dependent Precocious Puberty: Single-Center Experience from Western India. Indian Pediatr. 2023;60(6):463-466.
21. de Souza KBF, Veiga MSP, Martins GRF, da Silva AP, Fujita LGA, Tomé JM, et al. Assessment of Gonadotropin Concentrations Stimulated by Gonadotropin-Releasing Hormone Analog by Electrochemiluminescence in Girls with Precocious Puberty and Premature Thelarche. Horm Res Paediatr. 2021;94(11-12):433-440. doi: 10.1159/000521593
22. Sakornyutthadej N, Mahachoklertwattana P, Wankanit S, Poomthavorn P. Peak serum luteinising hormone cut-off during gonadotropin-releasing hormone analogue test for diagnosing central precocious puberty was lower in girls with obesity as compared with girls with normal weight. Clinical Endocrinology. 2024;100(4):368-378. doi: 10.1111/cen.15026
Downloads
Published
Issue
Section
License
Copyright (c) 2024 FACSALUD-UNEMI
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Todos los artículos de la Revista FACSalud UNEMI son difundidos bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
Los autores mantienen los derechos de autor, y, por lo tanto, son libres de compartir, copiar, distribuir, ejecutar y comunicar públicamente la obra bajo las condiciones siguientes: Reconocer los créditos de la obra especificada por el autor e indicar si se realizaron cambios (puede hacerlo de cualquier forma razonable, pero no de una manera que sugiera que el autor respalda el uso que hace de su obra. No utilizar la obra para fines comerciales. En caso de remezcla, transformación o desarrollo, no puede distribuirse el material modificado.
