Preclinical evaluation of the anti-ulcer Activity of the hydroalcoholic leaf extract of Piper carpunya (Guaviduca): ethanol-induced gastric ulcer model in wistar rats
DOI:
https://doi.org/10.29076/issn.2602-8360vol10iss18.2026pp33-40pKeywords:
Guaviduca (Piper Carpunya), anti-ulcer activity, gastroprotection, induced gastric ulcer, traditional medicine, wistar ratsAbstract
The objective of this research was to determine the preclinical anti-ulcer activity of the hydroalcoholic leaf extract of Guaviduca (Piper carpunya), following a quality control assessment of the raw plant material and the extract prepared at the Pilot Pharmacy Plant of the Technical University of Machala. The study was conducted using the methodology described in the CYTED Research Techniques Manual (1995), through the induction of acute gastric ulcer with 96% absolute ethanol in female Wistar rats (Rattus norvegicus). Four groups of five animals each were established: a Blank Group (no treatment), Control Group (96% ethanol), Reference Group (omeprazole), and Treatment Group (Guaviduca extract). All products under study were administered orally 30 minutes before the necrotizing agent. After this period, the animals were dissected and the stomachs removed for macroscopic evaluation. Severe ulcerative lesions were observed in the control group, while a marked reduction in such lesions was evident in the reference and treatment groups, with ulcer inhibition percentages of 46.2% and 50%, respectively. In conclusion, the hydroalcoholic extract of Guaviduca (Piper carpunya) exhibits anti-ulcer activity, providing protection and promoting the recovery of the gastric mucosa, as demonstrated by the macroscopic analysis of the stomachs.
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