OMEGA-3 FATTY ACID SUPPLEMENTATION ON MARKERS OF DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS

  • Jorly Mejia-Montilla Universidad del Zulia
  • Nadia Reyna-Villasmil Universidad del Zulia
  • Alfonso Bravo-Henríquez Universidad del Zulia
  • Eduardo Reyna-Villasmil Hospital Central “Dr. Urquinaona"
  • Andreina Fernández-Ramírez Universidad del Zulia
  • Pedro Herrera-Moya Universidad Estatal de Milagro
DOI: https://doi.org/10.29076/issn.2528-7737vol12iss31.2019pp11-18p

Abstract

The objective of research was to determine the effects of Omega-3 fatty acid supplementation on markers of disease activity in patients with rheumatoid arthritis. This study was conducted at the University Hospital in Maracaibo from June 2016 to December 2018. Patients were assigned to receive 3 grams/day of fish oil for 4 weeks and then 5 grams/day for a period of 4 weeks. The markers of disease activity (rheumatoid factor, erythrocyte sedimentation rate, and serum C-reactive protein) and the number of patients with clinical improvement were analyzed. A decrease in rheumatoid factor values (p <0.0001) as well as the values of rheumatoid factor, erythrocyte sedimentation rate, and serum C-reactive protein at 8 weeks compared to initial values (p <0.0001) was observed after 4 weeks of treatment. At 4 weeks, improvement in the number of inflamed joints and decrease in the amount of synovial fluid was observed (p <0.0001). It is concluded that Omega-3 fatty acid supplementation results in decreased markers of disease activity in patients with rheumatoid arthritis.

Downloads

Download data is not yet available.

References

Allen, A., Carville, S., y McKenna, F. (2018). Diagnosis and management of rheumatoid arthritis in adults: summary of updated NICE guidance. British Medical Journal, 362, k3015.

Berbert, AA., Kondo, CR., Almendra, CL., Matsuo, T., y Dichi, I. (2005). Supplementation of fish oil and olive oil in patients with rheumatoid arthritis. Nutrition, 21(2), 131-136.

Calder, PC. (2017). Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society Transactions, 45(5), 1105-1115.

Das, Gupta AB., Hossain, AK., Islam, MH., Dey, SR., y Khan, AL. (2009). Role of omega-3 fatty acid supplementation with indomethacin in suppression of disease activity in rheumatoid arthritis. Bangladesh Medical Research Council Bulletin, 35(2), 63-68.

Dawczynski, C., Schubert, R., Hein, G., Müller, A., Eidner, T., Vogelsang, H., Basu, S., y Jahreis G. (2009). Long-term moderate intervention with n-3 long-chain PUFA-supplemented dairy products: effects on pathophysiological biomarkers in patients with rheumatoid arthritis. British Journal of Nutrition, 101(10), 1517-1526.

Fialkow J. (2016). Omega-3 fatty acid formulations in cardiovascular disease: Dietary supplements are not substitutes for prescription products. American Journal of Cardiovascular Drugs, 16(4), 229-239.

Gioxari, A., Kaliora, AC., Marantidou, F., y Panagiotakos, DP. (2018). Intake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysis. Nutrition, 45, 114-124.e4.

Jagpal, A., y Navarro-Millán, I. (2018). Cardiovascular co-morbidity in patients with rheumatoid arthritis: a narrative review of risk factors, cardiovascular risk assessment and treatment. BMC Rheumatology, 2, 10.

Karlsson, JA., Neovius, M., Nilsson, JÅ., Petersson, IF., Bratt, J., van Vollenhoven, RF., Ernestam, S., y Geborek, P. (2013). Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in early rheumatoid arthritis: 2-year quality-of-life results of the randomised, controlled, SWEFOT trial. Annals of Rheumatic Disease, 72(12), 1927-1933.

Kim, JY., Lim, K., Kim, KH., Kim, JH., Choi, JS., y Shim, SC. (2018). N-3 polyunsaturated fatty acids restore Th17 and Treg balance in collagen antibody-induced arthritis. PLoS One, 13(3), e0194331.

Kremer, JM., Lawrence, DA., Jubiz, W., DiGiacomo, R., Rynes, R., Bartholomew, LE., y Sherman, M. (1990). Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheumatoid, 33(6), 810-820.

Kremer, JM., Lawrence, DA., Petrillo, GF., Litts, LL., Mullaly, PM., Rynes, RI., Stocker, RP., Parhami, N., Greenstein, NS., y Fuchs, BR. (1995). Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates. Arthritis Rheumatoid, 38(8), 1107-1114.

Lau, CS., Morley, KD., y Belch, JJ. (1993). Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients with mild rheumatoid arthritis--a double-blind placebo controlled study. British Journal of Rheumatology, 32(11), 982-989.

Lee, YH., Bae, SC., y Song, GG. (201). Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Archives of Medical Research, 43(5), 356-62.

Mazzone, R., Zwergel, C., Artico, M., Taurone, S., Ralli, M., Greco, A., y Mai, A. (2019). The emerging role of epigenetics in human autoimmune disorders. Clinical Epigenetics, 11(1), 34.

McDougall, J., Bruce, B., Spiller, G., Westerdahl, J., y McDougall, M. (2002). Effects of a very low-fat, vegan diet in subjects with rheumatoid arthritis. Journal of Alternative and Complementary Medicine, 8(1), 71-5.

McHugh, J. (2017). Rheumatoid arthritis: Regulating the osteoclast workforce. Nature Reviews Rheumatology, 13(9), 514.

Ortiz, EC., y Shinada, S. (2012). Evolution of classification criteria for rheumatoid arthritis: how do the 2010 criteria perform? Rheumatic Disease Clinics of North America, 38(2), 345-353.

Rajaei, E., Mowla, K., Ghorbani, A., Bahadoram, S., Bahadoram, M., y Dargahi-Malamir, M. (2015). The effect of Omega-3 fatty acids in patients with active rheumatoid arthritis receiving DMARDS therapy: Double-blind randomized controlled trial. Global Journal of Health Science, 8(7), 18-25.

Ramirez, JL., Gasper, WJ., Khetani, SA., Zahner, GJ., Hills, NK., Mitchell, PT., Sansbury, BE., Conte, MS., Spite, M., y Grenon, SM. (2019). Fish oil increases specialized pro-resolving lipid mediators in PAD (The OMEGA-PAD II Trial). Journal of Surgical Research, 238: 164-174.

Rawla, P. (2019). Cardiac and vascular complications in rheumatoid arthritis. Reumatologia, 57(1), 27-36.

Saidane, O., Semerano, L., y Sellam, J. (2019). Could omega-3 fatty acids prevent rheumatoid arthritis? Joint Bone Spine, 86(1), 9-12.

Sen, D., González-Mayda, M., y Brasington, RD Jr. (2014). Cardiovascular disease in rheumatoid arthritis. Rheumatic Disease Clinics of North America, 40(1), 27-49.

Singh, JA., y Cameron, DR. (2012). Summary of AHRQ's comparative effectiveness review of drug therapy for rheumatoid arthritis (RA) in adults--an update. Journal of Managed Care Pharmacy, 18(4 Supp C), S1-18.

Singh, S., Arora, RR., Singh, M., y Khosla, S. (2016). Eicosapentaenoic acid versus docosahexaenoic acid as options for vascular risk prevention: A fish story. American Journal of Therapeutics, 23(3), e905-e910.

Sköldstam, L., Börjesson, O., Kjällman, A., Seiving, B., y Akesson, B. (1992). Effect of six months of fish oil supplementation in stable rheumatoid arthritis. A double-blind, controlled study. Scandinavian Journal of Rheumatology, 21(4), 178-185.

Smolen, JS., Han, C., Bala, M., Maini, RN., Kalden, JR., van der Heijde, D., Breedveld, FC., Furst, DE., y Lipsky, PE (2005). Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study. Arthritis Rheumatoid. 2005;52(4):1020-1030.

Stamp, LK., James, MJ., y Cleland, LG. (2005). Diet and rheumatoid arthritis: a review of the literature. Seminars in Arthritis and Rheumatism, 35(2), 77-94.

Tanaka, Y. (2019). Clinical immunity in bone and joints. Journal of Bone and Mineral Metabolism, 37(1), 2-8.

Zhu, H., Deng, FY., Mo, XB., Qiu, YH., y Lei, SF. (2014). Pharmacogenetics and pharmacogenomics for rheumatoid arthritis responsiveness to methotrexate treatment: the 2013 update. Pharmacogenomics, 15(4), 551-566.

Published
2019-09-26
How to Cite
Mejia-Montilla, J., Reyna-Villasmil, N., Bravo-Henríquez, A., Reyna-Villasmil, E., Fernández-Ramírez, A., & Herrera-Moya, P. (2019). OMEGA-3 FATTY ACID SUPPLEMENTATION ON MARKERS OF DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS. Science Magazine Unemi, 12(31), 11-18. https://doi.org/10.29076/issn.2528-7737vol12iss31.2019pp11-18p
Issue
Vol 12 No 31 (2019): Septiembre-Diciembre
Section
Artículos Científicos

Authors can keep the copyright, granting the journal right of first publication. Alternatively, authors can transfer copyright to the journal, which allow authors non-commercial use of the work, including the right to place it in a file open access.

Most read articles by the same author(s)