OMEGA-3 FATTY ACID SUPPLEMENTATION ON MARKERS OF DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS
DOI:
https://doi.org/10.29076/issn.2528-7737vol12iss31.2019pp11-18pAbstract
The objective of research was to determine the effects of Omega-3 fatty acid supplementation on markers of disease activity in patients with rheumatoid arthritis. This study was conducted at the University Hospital in Maracaibo from June 2016 to December 2018. Patients were assigned to receive 3 grams/day of fish oil for 4 weeks and then 5 grams/day for a period of 4 weeks. The markers of disease activity (rheumatoid factor, erythrocyte sedimentation rate, and serum C-reactive protein) and the number of patients with clinical improvement were analyzed. A decrease in rheumatoid factor values (p <0.0001) as well as the values of rheumatoid factor, erythrocyte sedimentation rate, and serum C-reactive protein at 8 weeks compared to initial values (p <0.0001) was observed after 4 weeks of treatment. At 4 weeks, improvement in the number of inflamed joints and decrease in the amount of synovial fluid was observed (p <0.0001). It is concluded that Omega-3 fatty acid supplementation results in decreased markers of disease activity in patients with rheumatoid arthritis.
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