Omega 3 and its relationship with female infertility
DOI:
https://doi.org/10.29076/issn.2602-8360vol8iss15.2024pp152-159pKeywords:
fish oil, polyunsaturated fatty acids, female infertility, omega 3, PUFAAbstract
Female infertility is considered a complex phenomenon, influenced by several individual and environmental factors, which imply a global challenge. It is classified as primary, characteristic of the absence of a previous conception, and secondary after achieving a pregnancy or successful previous conception. Factors such as constant exposure to pollutants and chemicals, current lifestyles, and delayed motherhood periods play a crucial role in its prevalence. Additionally, pathological conditions are highlighted, including: polycystic ovary syndrome, endometriosis, and uterine fibroids, which are significant in this context. Global health organizations estimate that one in six couples faces difficulty conceiving. In this regard, the impact of omega-3 consumption on female infertility is being investigated, enhancing ovocyte quality and reducing inflammation; although the evidence remains contradictory, underlining the need for a more in-depth approach in assisted reproduction techniques (ART). Studies suggest that ovarian stimulation reduces spontaneous abortions and optimizes uterine conditions to improve embryo quality. Integrating supplements that favor these conditions could be fundamental in managing female infertility.
Downloads
References
1. INEC. Proyecciones de Población y Omisión Censal. 2024;1–49. Disponible en: https://www.ecuadorencifras.gob.ec/documentos/web-inec/Poblacion_y_Demografia/Proyecciones_Poblacionales/censo_2022/2024-02-18_Proyeccciones_presenta_VF.pdf
2. Organización Panamericana de la Salud. La OMS alerta de que una de cada seis personas padece infertilidad. 2023;1–3. Disponible en: https://www.paho.org/es/noticias/4-4-2023-oms-alerta-que-cada-seis-personas-padece-infertilidad
3. Abodi M, De Cosmi V, Parazzini F, Agostoni C. Omega-3 fatty acids dietary intake for oocyte quality in women undergoing assisted reproductive techniques: A systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2022;275: 97-105. doi: 10.1016/j.ejogrb.2022.06.019.
4. Yavuzcan A. The Omega-3 Polyunsaturated Fatty Acid Supplementation and Female Infertility. International Journal of Women’s Health and Reproduction Sciences. 2022;10(2): 63–64. doi:10.15296/ijwhr.2022.12
5. James A, Wang Y. Characterization, health benefits and applications of fruits and vegetable probiotics. CYTA - Journal of Food. 2019;17(1):770–80. doi: 10.1080/19476337.2019.1652693
6. Sadeghi F, Alavi-Naeini A, Mardanian F, Ghazvini MR, Mahaki B. Omega-3 and vitamin E co-supplementation can improve antioxidant markers in obese/overweight women with polycystic ovary syndrome. International Journal for Vitamin and Nutrition Research. 2020;90(5–6):477–83. doi: 10.1024/0300-9831/a000588
7. Kohil A, Chouliaras S, Alabduljabbar S, Lakshmanan AP, Ahmed SH, Awwad J, et al. Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review. Front Nutr. 2022; 927972. doi: 10.3389/fnut.2022.927972
8. Gürbüz T. A comprehensive survey: prevention of female infertility by nutrition. Journal of Health Sciences and Medicine. 2023;6(4):845–51. doi: 10.32322/jhsm.1291555
9. Aoun A, Khoury V El, Malakieh R. Can Nutrition Help in the Treatment of Infertility? Prev Nutr Food Sci. 2021; 26(2):109–120. doi: 10.3746/pnf.2021.26.2.109
10. Lass A, Belluzzi A. Omega-3 polyunsaturated fatty acids and IVF treatment. Reprod Biomed Online. 2019; 38(1):95-99. doi: 10.1016/j.rbmo.2018.10.008
11. Zarezadeh R, Mehdizadeh A, Leroy JLMR, Nouri M, Fayezi S, Darabi M. Action mechanisms of n‐3 polyunsaturated fatty acids on the oocyte maturation and developmental competence: Potential advantages and disadvantages. J Cell Physiol. 2019;234(2):1016–29. doi: 10.1002/jcp.27101
12. Salas-Huetos A, Arvizu M, Mínguez-Alarcón L, Mitsunami M, Ribas-Maynou J, Yeste M, et al. Women’s and men’s intake of omega-3 fatty acids and their food sources and assisted reproductive technology outcomes. Am J Obstet Gynecol. 2022;227(2):246.e1-246.e11. doi: 10.1016/j.ajog.2022.03.053
13. Stanhiser J, Jukic AMZ, McConnaughey DR, Steiner AZ. Omega-3 fatty acid supplementation and fecundability. Human Reproduction. 2022;37(5):1037–46. doi: 10.1093/humrep/deac027
14. Barsky M, Blesson CS. Oocytes, obesity, and omega-3 fatty acids. Fertil Steril. 2020;113(1):71–72. doi: 10.1016/j.fertnstert.2019.09.022
15. Stanhiser J, Jukic AMZ, Steiner AZ. Serum omega-3 and omega-6 fatty acid concentrations and natural fertility. Human Reproduction. 2020;35(4):950–957. doi: 10.1093/humrep/dez305
16. Wang R, Feng Y, Chen J, Chen Y, Ma F. Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years. Front Public Health. 2022; 10:938343. doi: 10.3389/fpubh.2022.938343
17. De Cosmi V, Cipriani S, Parazzini F, Ricci E, Esposito G, Noli S, et al. Fatty acids intake and outcomes of assisted reproduction in women referring to an Italian Fertility Service: cross‐sectional analysis of a prospective cohort study. Journal of Human Nutrition and Dietetics. 2022; 35(5):833-844. doi: 10.1111/jhn.12982
18. Budani MC, Tiboni GM. Nutrition, female fertility and in vitro fertilization outcomes. Reproductive Toxicology. 2023;118:108370. doi: 10.1016/j.reprotox.2023.108370
19. Trop-Steinberg S, Gal M, Azar Y, Kilav-Levin R, Heifetz EM. Effect of omega-3 supplements or diets on fertility in women: A meta-analysis. Heliyon. 2024;10(8):e29324. doi: 10.1016/j.heliyon.2024.e29324
20. Hohos NM, Elliott EM, Cho KJ, Lin IS, Rudolph MC, Skaznik-Wikiel ME. High-fat diet-induced dysregulation of ovarian gene expression is restored with chronic omega-3 fatty acid supplementation. Mol Cell Endocrinol. 2020;499:110615. doi: 10.1016/j.mce.2019.110615
21. Wang Y, Xie Z, Bo Y. Causal Effect of Omega-3 on male infertility and female infertility: A Mendelian Randomization Study. Research Square. 2024. doi:10.21203/rs.3.rs-3966971/v1
22. Yang, Q., Wuliu, J., Zeng, L. et al. Association between a body shape index and female infertility: a cross-sectional study. BMC Women's Health. 2024; 486. doi: 10.1186/s12905-024-03335-1
23. Eskew AM, Bedrick BS, Riley JK, Jungheim ES. Relationship between omega-3 and omega-6 serum free fatty acids and ovarian reserve. Fertil Steril. 2019;111(4):e41.
24. Hong Y, Jin X, Shi L. Association between polyunsaturated fatty acids and depression in women with infertility: a cross-sectional study based on the National Health and Nutrition Examination Survey. Front Psychiatry. 2024; 15:1345815. doi: 10.3389/fpsyt.2024.1345815
25. Yuan J, Wen X, Jia M. Efficacy of omega-3 polyunsaturated fatty acids on hormones, oxidative stress, and inflammatory parameters among polycystic ovary syndrome: a systematic review and meta-analysis. Ann Palliat Med. 2021; 10(8):8991-9001. doi: 10.21037/apm-21-2018
26. Jahangirifar M, Taebi M, Nasr-Esfahani MH, Heidari-Beni M, Asgari GH. Dietary Fatty Acid Intakes and the Outcomes of Assisted Reproductive Technique in Infertile Women. Journal of Reproduction & Infertility. 2021; 22(3):173-183. doi: 10.18502/jri.v22i3.6718
27. Buch S. P–585 The influence of omega–3 fatty acids on female fertility in assisted reproductive technology. Human Reproduction. 2021;36(Supplement_1). doi: 10.1093/humrep/deab130.584
28. Asif H, Kabir M, Ashfaq M, Arshad M, Saeed S. Dietary Pattern Among Infertile Women: A Cross-sectional Study. DIET FACTOR Journal of Nutritional & Food Sciences. 2021;2(2):13–18. doi: 10.54393/df.v2i2.21
29. Mínguez-Alarcón L, Williams PL, Souter I, Sacha C, Amarasiriwardena CJ, Ford JB, et al. Hair mercury levels, intake of omega-3 fatty acids and ovarian reserve among women attending a fertility center. Int J Hyg Environ Health. 2021; 237:113825. doi: 10.1016/j.ijheh.2021.113825
Downloads
Published
Issue
Section
License
Copyright (c) 2024 FACSALUD-UNEMI
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Todos los artículos de la Revista FACSalud UNEMI son difundidos bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
Los autores mantienen los derechos de autor, y, por lo tanto, son libres de compartir, copiar, distribuir, ejecutar y comunicar públicamente la obra bajo las condiciones siguientes: Reconocer los créditos de la obra especificada por el autor e indicar si se realizaron cambios (puede hacerlo de cualquier forma razonable, pero no de una manera que sugiera que el autor respalda el uso que hace de su obra. No utilizar la obra para fines comerciales. En caso de remezcla, transformación o desarrollo, no puede distribuirse el material modificado.
